A Handbook of Derivatives for Mass Spectrometry

No books have been completely devoted to all aspects of derivatisation for various mass spectrometric investigations, especially for the comparatively new soft-ionisation techniques. Considerable experience in mass spectrometric practice and in the development and application of preliminary chemical modification of organic compounds impelled the authors to write this book. It is based upon the eight reviews published in European Journal of Mass Spectrometry with the addition of a chapter devoted to derivatisation for the soft-ionisation MS of large molecules.

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  • £80.00
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  • Weight
    1000 g
  • ISBN
    978-1-901019-09-4

Each chapter looks at a particular area of derivatisation and includes extensive references to the literature for further research where necessary. There are nearly 1800 references, which, as well as full bibliographic information, include chapter/paper titles where appropriate and Digital Object Identifiers (DOIs) to allow easy retrieval of the online version of the referenced publication. The emergence of atmospheric pressure ionisation and other soft ionisation techniques has not diminished the interest in such chemical techniques, as witnessed by the many chemical tags used in quantitative proteomics (Chapter 9). The last two chapters, a substantial part of the book, deal with derivatisation for use with soft ionisation of both small and large molecules.

The main aim of the book is to acquaint the reader with the major methods for the preliminary chemical transformation of samples for mass spectrometric analysis in order to improve their physical and physico-chemical properties, to enhance the sensitivity and information content of various mass spectrometric methods and to assist precise quantitative analysis. Both the chemical aspects of derivatisation (reagents and reaction conditions) and mass spectrometric features of derivatives are considered in the book.

  • Preface/Introduction
  • Ch.1: Silylation
  • Ch.2: Acylation
  • Ch.3: Alkylation (arylation)
  • Ch.4: Formation of cyclic derivatives
  • Ch.5: Specific derivatisation of monofunctional compounds
  • Ch.6: Formation of mixed derivatives of polyfunctional compounds
  • Ch.7: On-line derivatisation/degradation
  • Ch.8: Soft ionisation mass spectrometry of small mlecules
  • Ch.9:”Soft” ionisation mass spectrometry of large molecules
  • Appendix
  • Index

Professor John M. Halket is a visiting professor at King’s College London in the department of Forensic Science and Drug Monitoring. His research interests are Development and application of chromatographic and mass spectrometric methods in the biosciences, particularly drug analysis, metabolic profiling and proteomics. Contractor to pharmaceutical companies, UK Food Standards Agency, NHS (Consultant Clinical Scientist) and NIST (USA).

Professor Vladimir G. Zaikinis head of Laboratory at A.V. Topchiev Institute of Petrochemical Synthesis in Moscow. His research activities have focused on mass spectrometry, as reflected in nearly 300 publications.

  • Authors
    Vladimir Zaikin and John Halket
  • Binding
    Hardback
  • Pages
    513
  • Weight (g)
    1000
  • ISBN-13
    978-1-901019-09-4

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