Statistics and Chemometrics for Analytical Chemistry- 6th Edn

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This popular textbook gives a clear account of the principles of the main statistical methods used in modern analytical laboratories. Such methods underpin high quality analyses in areas such as the safety of food, water and medicines, environmental monitoring, and chemical manufacturing.

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The treatment throughout emphasises the underlying statistical ideas, and no detailed knowledge of mathematics is required. There are numerous worked examples, including the use of Microsoft Excel and Minitab, and a large number of student exercises, many of them based on examples from the analytical literature. 

This book is aimed at undergraduate and graduate courses in Analytical Chemistry and related topics. It will also be a valuable resource for researchers and chemists working in analytical chemistry.

Features of new edtion

  • introduction to Bayesian methods
  • additions to cover method validation and sampling uncertainty
  • extended treatment of robust statistics
  • new material on experimental design
  • additions to sections on regression and calibration methods
  • updated instructor's Manual
  • improved website including further exercises for lecturers and students

1. Introduction

  • 1.1 Analytical problems
  • 1.2 Errors in qunatitative analysis
  • 1.3 Types of error
  • 1.4 Random and systematic errors in titrimetric analysis
  • 1.5 Handling systematic errors
  • 1.6 Planning and design of experiments
  • 1.7 Calculators and computers in statistical calculations

2. Statistics of Repeated Measurements

  • 2.1 Mean and standard deviation
  • 2.2 The distribution of repeated measurements
  • 2.3 Log-normal distribution
  • 2.4 Definition of a 'sample'
  • 2.5 The sampling distribution of the mean
  • 2.6 Confidence limits of the mean for large samples
  • 2.7 Confidence limits of the mean for small samples
  • 2.8 Presentation of results
  • 2.9 Other uses of confidence limits
  • 2.10 Confidence limits of the geometric mean for a log-normal distribution
  • 2.11 Propagation of random error
  • s2.12 Propagation of systematic errors

3. Significance Tests

  • 3.1 Introduction
  • 3.2 Comparison of an experimental mean with a known value
  • 3.3 Comparison of two experimental means
  • 3.4 Paired t-test
  • 3.5 One-sided and two-sided tests
  • 3.6 F-test for the comparison of standard deviations
  • 3.7 Outliers
  • 3.8 Analysis of variance
  • 3.9 Comparison of several means
  • 3.10 The arithmetic of ANOVA calculations
  • 3.11 The chi-squared test
  • 3.12 Testing for normality of distribution
  • 3.13 Conclusions from significance tests
  • 3.14 Bayesian Statistics

4. The Quality of Analytical Measurements

  • 4.1 Introduction
  • 4.2 Sampling
  • 4.3 Separation and estimation of variances using ANOVA
  • 4.4 Sampling strategy
  • 4.5 Quality control methods - Introduction
  • 4.6 Stewhart charts for mean value
  • s4.7 Stewhart charts for ranges
  • 4.8 Establishing the process capability
  • 4.9 Average run length: cusum charts
  • 4.10 Zone control charts (J-charts)
  • 4.11 Proficiency testing schemes
  • 4.12 Method performance studies (collaborative trials)
  • 4.13 Uncertainty
  • 4.14 Acceptable sampling
  • 4.15 Method validation

5. Calibration Methods in Instumental Analysis

  • 5.1 Introduction: instrumentational analysis
  • 5.2 Calibration graphs in instrumental analysis
  • 5.3 The product-moment correlation coefficient
  • 5.4 The line of regression of y on x
  • 5.5 Errors in the slope and intercept of the regression line
  • 5.6 Calculation of a concentration and its random error
  • 5.7 Limits of detection
  • 5.8 The method of standard additions
  • 5.9 Use of regression lines for comparing analytical methods
  • 5.10 Weighted regression lines
  • 5.11 Intersection of two straight lines
  • 5.12 ANOVA and regression calculations
  • 5.13 Curvilinear regression methods - Introduction
  • 5.14 Curve fitting
  • 5.15 Outliers in regression

6. Non-parametric and Robust Method

  • s6.1 Introduction
  • 6.2 The median: initial data analysis
  • 6.3 The sign test
  • 6.4 The Wald-Wolfowitz runs test
  • 6.5 The Wilcoxon signed rank test
  • 6.6 Simple tests for two independent samples
  • 6.7 Non-parametric tests for more than two samples
  • 6.8 Rank correlation
  • 6.9 Non-parametric regression methods
  • 6.10 Robust methods: introduction
  • 6.11 Simple robust methods: trimming and winsorization
  • 6.12 Further robust estimates of location and spread
  • 6.13 Robust ANOVA
  • 6.14 Robust regression methods
  • 6.15 Re-sampling statistics
  • 6.16 Conclusions

7. Experiimental Design and Optimization

  • 7.1 Introduction
  • 7.2 Randomization and blocking
  • 7.3 Two-way ANOVA
  • 7.4 Latin squares and other designs
  • 7.5 Interactions
  • 7.6 Identifying the important factors: factorial designs
  • 7.7 Fractional factorial designs
  • 7.8 Optimization: basic principles and univariate methods
  • 7.9 Optimization using the alternating variable search method
  • 7.10 The method of steepest ascent
  • 7.11 Simplex optimization
  • 7.12 Simulated annealing

8. Multivariate Analysis

  • 8.1 Introduction
  • 8.2 Initial analysis
  • 8.3 Prinicipal component analysis
  • 8.4 Cluster analysis8.5 Discriminant analysis8.6 K-nearest neighbour method8.7 Disjoint class modelling
  • 8.8 Regression methods
  • 8.9 Multiple linear regression
  • 8.10 Principal component regression
  • 8.11 Partial least squares regression
  • 8.12 Natural computation methods; artificial neural networks
  • 8.13


Solutions to Exercises

Appendix 1 Commonly used statistical significance tests

Appendix 2 Statistical tablesIndex

    • Weight
      1001 g
    • SKU
  • Authors
    James N Miller and Jane C Miller
  • Binding
  • Pages
  • Weight (g)
  • ISBN-13

Professor James Miller is Emeritus Professor of Analytical Chemistry at Loughborough University. He has published numerous reviews and papers on analytical techniques and been awared the SAC Silver Medal, the Theophilus Redwood Lectureship and the SAC Gold Medal by the Royal Society of Chemistry. A past President of the Analytical Division of the RSC, he is a former member of the Society's Council and has served on the editorial boards of many analytical and spectroscopic journals.

Dr Jane Miller completed a PhD at Cambridge University's Cavendish Laboratory and is an experience teacher of mathematics and physics at higher education and 6th form levels. She holds an MSc in Applied Statistics and is the Author of several specialist A-level statistics texts.

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