Process Analytical Technology 2nd Edition
Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries
Process Analytical Technology (ISBN 978-0470722077) explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised,and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added.
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Process Analytical Technology includes:
- Implementation of Process Analytical Technologies
- UV-Visible Spectroscopy for On-line Analysis
- Infrared Spectroscopy for Process Analytical Applications
- Process Raman Spectroscopy
- Process NMR Spectrscopy: Technology and On-line Applications
- Fluorescent Sensing and Process Analytical Applications
- Chemometrics in Process Analytical Technology (PAT)
- On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry
- Future Trends for PAT for Increased Process Understanding and Growing Applications in Bio manufacturing
- NIR Chemical Imaging
This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT.
It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focusing on PAT.
Review from the First Edition
"The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology."
Chapter 1: Overview of Process Analysis and PAT (Jason E. Dickens)
Chapter 2: Implementation of Process Analytical Technologies (Robert Guenard and Gert Thurau)
Chapter 3: Process Sampling: Theory of Sampling the Missing Link in Process Analytical Technologies (PAT) (Kim H. Esbensen and Peter Paasch–Mortensen)
Chapter 4: UV–visible Spectroscopy for On–line Analysis (Marcel A. Liauw, Lewis C. Baylor and Patrick E. O Rourke)
Chapter 5: Near–infrared Spectroscopy for Process Analytical Technology: Theory, Technology and Implementation (Michael B. Simpson)
Chapter 6: Infrared Spectroscopy for Process Analytical Applications (John P. Coates)
Chapter 7: Raman Spectroscopy (Nancy L. Jestel)
Chapter 8: Near–infrared Chemical Imaging for Product and Process Understanding (E. Neil Lewis, Joseph W. Schoppelrei, Lisa Makein, Linda H. Kidder and Eunah Lee)
Chapter 9: Acoustic Chemometric Monitoring of Industrial Production Processes (Maths Halstensen and Kim H. Esbensen)
Chapter 10: Process NMR Spectroscopy: Technology and On–line Applications (John C. Edwards and Paul J. Giammatteo) Chapter 11: Fluorescent Sensing and Process Analytical Applications (Jason E. Dickens)
Chapter 12: Chemometrics in Process Analytical Technology (PAT) (Charles E. Miller)
Chapter 13: On–line PAT Applications of Spectroscopy in the Pharmaceutical Industry (Brandye Smith–Goettler)
Chapter 14: NIR Spectroscopy in Pharmaceutical Analysis: Off–line and At–line PAT Applications (Marcelo Blanco Romía and Manel Alcalá Bernárdez)
Chapter 15: Near–infrared Spectroscopy (NIR) as a PAT Tool in the Chemical Industry: Added Value and Implementation Challenges (Ann M. Brearley and Susan J. Foulk)
Chapter 16: Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing (Katherine A. Bakeev and Jose C. Menezes)
EditorKatherine A. Bakeev
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