PAT and Beyond
This Thesis presents the research performed during the PhD project between Novo Nordisk A//s in Denmark and The University of Amsterdam.
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The thesis title 'PAT and Beyond' is selected because a great deal of the research presented in the thesis can be applied to a wide selection of process analyzers and monitoring systems in general. Also the ideas for process models laided down in chapter four are applicable for many different PAT systems. Finally PAT is in focus when presenting future research ideas.
In the first chapter the reader will be introduced to some of the regulatory initiatives that facilitate the transition that is starting to take place in the pharmaceutical industry. The second chapter provides a short description of the NIR theory. Chapter three explains the the two manufacturing processes of pharmaceutical drugs and chapter 4 covers one of the accepted papers that were produced in the thesis as an extended version. Finally, concluding remarks and suggestions for future research are dealt with in chapter five.
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